Microstructural visual system changes in AQP4-antibody–seropositive NMOSD
نویسندگان
چکیده
منابع مشابه
Microstructural visual system changes in AQP4-antibody–seropositive NMOSD
OBJECTIVE To trace microstructural changes in patients with aquaporin-4 antibody (AQP4-ab)-seropositive neuromyelitis optica spectrum disorders (NMOSDs) by investigating the afferent visual system in patients without clinically overt visual symptoms or visual pathway lesions. METHODS Of 51 screened patients with NMOSD from a longitudinal observational cohort study, we compared 6 AQP4-ab-serop...
متن کاملNormal volumes and microstructural integrity of deep gray matter structures in AQP4+ NMOSD
OBJECTIVE To assess volumes and microstructural integrity of deep gray matter structures in a homogeneous cohort of patients with neuromyelitis optica spectrum disorder (NMOSD). METHODS This was a cross-sectional study including 36 aquaporin-4 antibody-positive (AQP4 Ab-positive) Caucasian patients with NMOSD and healthy controls matched for age, sex, and education. Volumetry of deep gray mat...
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Neuromyelitis optica spectrum disorder (NMOSD) associated with aquaporin-4 antibody (AQP4-Ab) predominantly targets the optic nerve and spinal cord and is characterized by frequent relapses and accrual of irreversible disability. Variations in clinical course may include an initial or predominant involvement in extra spinal/optic nerve locations and a benign course marked by mild attacks and mi...
متن کاملChanges in AQP4 expression and the pathology of injured cultured astrocytes after AQP4 mRNA silencing
Objectives: In this study, we investigated AQP4 expression in injured astrocytes in vitro, as well as the influence of AQP4 levels on pathology using gene silencing. Methods: Astrocytes were cultured and the mechanical scratch method was used to simulate an injury. Cells were randomly divided into the control group, injury group, Scramble group (P-AQP4), and RNA interference group (siRNA-AQP4),...
متن کاملFoveal thinning in neuromyelitis optica
Patients with neuromyelitis optica spectrum disorder (NMOSD) typically manifest recurrent episodes of optic neuritis (ON) and myelitis. Recently revised diagnostic criteria do not restrict the diagnosis of NMOSD to patients associated with elevation of anti–aquaporin 4 antibody (AQP4Ab), capable of causing destruction of astrocytes expressing AQP4. If compatible clinical and radiologic features...
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ژورنال
عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation
سال: 2017
ISSN: 2332-7812
DOI: 10.1212/nxi.0000000000000334